Impaired glutathione (GSH) synthesis and dopaminergic transmission are important factors in the pathophysiology of schizophrenia. Our research aimed to assess the effects of l-buthionine-(S,R)-sulfoximine (BSO), a GSH synthesis inhibitor, and GBR 12909, a dopamine reuptake inhibitor, administered alone or in combination, to Sprague–Dawley rats during early postnatal development (p5–p16), on the levels of GSH, sulfur amino acids, global DNA methylation, and schizophrenia-like behavior. GSH, methionine (Met), homocysteine (Hcy), and cysteine (Cys) contents were determined in the liver, ki
The dynamic viscosity and rheological properties of two different non-aqueous graphene nano-plates-based nanofluids are experimentally investigated in this paper, focusing on the effects of solid volume fraction and shear rate. For each nanofluid, four solid volume fractions have been considered ranging from 0.1% to 1%. The rheological characterization of the suspensions was performed at 20 ∘C, with shear rates ranging from 10−1s−1 to 103s−1, using a cone-plate rheometer. The Carreau–Yasuda model has been successfully applied to fit most of the rheological measurements. Although i
Cement fly ash gravel (CFG) pile composite foundation is an effective and economic foundation treatment approach, which is significant to building foundation, subgrade construction, and so forth. The present paper aims at investigating the settlement behaviors of saturated tailings dam soft ground under CFG pile composite foundation treatment, in which FEM and laboratory model test were utilized. The proposed findings demonstrate that CFG pile treatment is effective in reinforcing saturated tailings dam and loading has little influence on settlement of soil between piles. The variation of s
The utilization of recycled coarse aggregate (RCA) from construction and demolition waste (CDW) is a sustainable solution to protect the fragile natural environment and save the diminishing natural resources. The current study was aimed at exploring the impact resistance and mechanical properties of recycled aggregate concrete (RAC) affected by hooked-end steel fiber (HF) and crimped steel fiber (CF). Fifteen concrete mixtures considering different RCA substitution ratio, steel fiber dosage, and steel fiber shapes were designed. Meanwhile, a statistical analysis method-based Weibull distrib
Earthquakes worldwide highlight the seismic vulnerability of reinforced concrete (RC) bridge columns. RC bridges are likely to collapse or lose service function due to damage to the bridge columns from strong earthquakes. Rapid repair of RC bridge columns is of great significance for maintaining traffic lines for emergency rescue work after earthquakes. In this study, an improved rapid repair method was developed to restore the bearing capacity of a damaged precast column after earthquake damage. A cyclic loading test was performed to simulate the seismic loading. The original column and th