Structural frame systems that consists of concrete-encased-steel-embedded composite columns and reinforced concrete beams are typically used in mid-rise to tall buildings. In order to understand their overall structural behavior, a total of 12 frame models with high and low ductility features were constructed and analyzed using LS-DYNA software. Two of these models were validated using the results of previously tested frames. The remaining 10 models were studied to predict the behavior of frames with varying concrete strengths, reinforcement configurations, and structural steel sections und